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AL7A1 rabbit pAb

CAT: 0855-ES18406-01Size: 50 µLDry Ice: NoHazardous: No
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Background
The protein encoded by this gene is a member of subfamily 7 in the aldehyde dehydrogenase gene family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular member has homology to a previously described protein from the green garden pea, the 26g pea turgor protein. It is also involved in lysine catabolism that is known to occur in the mitochondrial matrix. Recent reports show that this protein is found both in the cytosol and the mitochondria, and the two forms likely arise from the use of alternative translation initiation sites. An additional variant encoding a different isoform has also been found for this gene. Mutations in this gene are associated with pyridoxine-dependent epilepsy. Several related pseudogenes have also been identified. [provided by RefSeq, Jan 2011]
Description
The protein encoded by this gene is a member of subfamily 7 in the aldehyde dehydrogenase gene family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular member has homology to a previously described protein from the green garden pea, the 26g pea turgor protein. It is also involved in lysine catabolism that is known to occur in the mitochondrial matrix. Recent reports show that this protein is found both in the cytosol and the mitochondria, and the two forms likely arise from the use of alternative translation initiation sites. An additional variant encoding a different isoform has also been found for this gene. Mutations in this gene are associated with pyridoxine-dependent epilepsy. Several related pseudogenes have also been identified. [provided by RefSeq, Jan 2011],
UniProt
P49419
Swiss Prot
P49419
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human AL7A1 AA range: 229-279
Target
AL7A1
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
[Isoform 2]: Cytoplasm, cytosol . Nucleus .; [Isoform 1]: Mitochondrion .
Gene ID (Human)
501

UniProtKB · P49419

Alpha-aminoadipic semialdehyde dehydrogenase

AL7A1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P49419
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ALDH7A1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Alpha-AASA dehydrogenase
EC number
1.2.1.31
Processing
Precursor
Secondary accessions
B2R669, B4DIC7, B4DMA0, E7EPT3, O14619, Q6IPU8, Q9BUL4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCytoplasmGolgi apparatusMembraneMitochondrionNucleus

Disease

Disease variantEpilepsy

Ligand

NAD

Molecular function

Oxidoreductase

Domain

Transit peptide

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