LIT-927

• Description :

  LIT-927 is a locally and orally active CXCL12 neutraligand with anti-inflammatory effect, with a Ki of 267 nM for CXCL12 binding to its specific receptor CXCR4[1] .

• UNSPSC :

  12352005

• Target :

  CXCR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Immunology/Inflammation

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Inflammation/Immunology; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/LIT-927.html

• Concentration :

  10mM

• Purity :

  99.86

• Solubility :

  DMSO : 12.5 mg/mL (ultrasonic)

• Smiles :

  ClC1=CC=C(C(C=C(C2=CC=C(O)C(OC)=C2)N3)=NC3=O)C=C1

• Molecular Formula :

  C17H13ClN2O3

• Molecular Weight :

  328.75

• References & Citations :

  [1]Regenass P, et al. Discovery of a Locally and Orally Active CXCL12 Neutraligand (LIT-927) with Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia. J Med Chem. 2018 Sep 13;61 (17) :7671-7686.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CXCR4

• CAS Number :

  [2172879-52-4]