SKS-927

CAT: 0804-HY-10188Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-10188Size:1 Each
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Description
SKS-927 is a Src kinase inhibitor, with an IC50 value of 3.9 nM. SKS-927 inhibits the proliferation of Src-transformed rat fibroblasta, with an IC50 value of 73 nM. SKS-927 exhibits an IC50 value of 720 nM against EGFR. SKS-927 can be used for the study of cancer and osteoporosis[1].
CAS Number
[885482-95-1]
UNSPSC
12352005
Target
EGFR; Src
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
N#CC1=CN=C2C=C(C(OC)=CC2=C1NC3=CC(OC)=C(C=C3Cl)Cl)C#CCCN4CCN(CC4)C
Molecular Formula
C27H27Cl2N5O2
Molecular Weight
524.44
References & Citations
[1]Boschelli DH, et al. Inhibition of Src kinase activity by 7-ethynyl-4-phenylamino-3-quinolinecarbonitriles: identification of SKS-927. Bioorg Med Chem Lett. 2007 Mar 1;17 (5) :1358-61.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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