SKS-927

• Description :

  SKS-927 is a Src kinase inhibitor, with an IC50 value of 3.9 nM. SKS-927 inhibits the proliferation of Src-transformed rat fibroblasta, with an IC50 value of 73 nM. SKS-927 exhibits an IC50 value of 720 nM against EGFR. SKS-927 can be used for the study of cancer and osteoporosis[1].

• UNSPSC :

  12352005

• Target :

  EGFR; Src

• Related Pathways :

  JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Field of Research :

  Cancer

• Smiles :

  N#CC1=CN=C2C=C(C(OC)=CC2=C1NC3=CC(OC)=C(C=C3Cl)Cl)C#CCCN4CCN(CC4)C

• Molecular Formula :

  C27H27Cl2N5O2

• Molecular Weight :

  524.44

• References & Citations :

  [1]Boschelli DH, et al. Inhibition of Src kinase activity by 7-ethynyl-4-phenylamino-3-quinolinecarbonitriles: identification of SKS-927. Bioorg Med Chem Lett. 2007 Mar 1;17 (5) :1358-61.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [885482-95-1]