Reverse T3

• Description:

  Reverse T3 is a thyroid hormone that can be generated by deiodination of the prohormone thyroxine[1]. Reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes[2].

• Product Name Alternative:

  3′,5′,3-Triiodothyronine

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Thyroid Hormone Receptor

• Type:

  Reference compound

• Related Pathways:

  Vitamin D Related/Nuclear Receptor

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/reverse-t3.html

• Concentration:

  10mM

• Purity:

  97.97

• Solubility:

  DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  IC(C=C(C=C1)C[C@H](N)C(O)=O)=C1OC2=CC(I)=C(C(I)=C2)O

• Molecular Formula:

  C15H12I3NO4

• Molecular Weight:

  650.97

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Nicod P, et al. Radioimmunoassay for 3,3',5'-triiodo-L-thyronine in unextracted serum: method and clinical results. J Clin Endocrinol Metab. 1976 May;42 (5) :823-9. |[2]Rebolledo RA, et al. Anti-Apoptotic Effects of 3,3',5-Triiodo-L-Thyronine in the Liver of Brain-Dead Rats. PLoS One. 2015 Oct 5;10 (10) :e0138749. |[3]Verga Falzacappa C, et al. 3,5,3'-triiodothyronine (T3) is a survival factor for pancreatic beta-cells undergoing apoptosis. J Cell Physiol. 2006 Feb;206 (2) :309-21.|[4]Bronson Kumar Khangembam, et al. Effect of cortisol and triiodothyronine bath treatments on the digestive enzyme profile and growth of atla catla larvae during ontogenic development, Aquaculture Research.13054, 48, 5, (2173-2185), (2016) .

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [5817-39-0]