RS-25344

• Description:

  RS-25344 is a selective inhibitor of phosphodiesterase type IV (PDE4) . RS-25344 increases intracellular cAMP (cyclic adenosine phosphate) concentration by inhibiting PDE4 activity. RS-25344 can be used in the study of inflammation, immune diseases, neurodegenerative diseases and cardiovascular diseases[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319

• Target:

  Phosphodiesterase (PDE)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/rs-25344.html

• Smiles:

  O=C1N(C2=CC=CC([N+]([O-])=O)=C2)C3=NC=CC=C3C(N1CC4=CC=NC=C4)=O

• Molecular Formula:

  C19H13N5O4

• Molecular Weight:

  375.34

• Precautions:

  P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

• References & Citations:

  [1]Fisch J D, et al. Enhancement of motility and acrosome reaction in human spermatozoa: differential activation by type-specific phosphodiesterase inhibitors[J]. Human Reproduction (Oxford, England), 1998, 13 (5) : 1248-1254.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  152814-89-6