MARK-IN-1

• UNSPSC Description:

  MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of <0.25 nM.

• Target Antigen:

  AMPK

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;PI3K/Akt/mTOR

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/MARK-IN-1.html

• Purity:

  98.48

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=CC(C2=C3N=CC(C4=CN(C)N=C4)=CN3N=C2)=C(C)S1)N[C@H]5C(F)(F)CCC[C@H]5N

• Molecular Weight:

  471.53

• References & Citations:

  [1]Sloman DL, et al. Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4362-6.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Clinical Information:

  No Development Reported

• CAS Number:

  1109283-93-3