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MARK4 inhibitor 1

CAT: 0804-HY-114317-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114317-01Size:5 mg
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Description
MARK4 inhibitor 1 is a potent and selective microtubule affinity-regulating kinase 4 (MARK4) inhibitor, with an IC50 of 1.54 μM. MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis[1].
CAS Number
2271081-58-2
Product Name Alternative
AZD-3355 (hydrochloride), AM152 (sodium), AZD-3355 (napadisylate)
UNSPSC
12352005
Target
AMPK; Apoptosis; MARK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mark4-inhibitor-1.html
Purity
98.29
Solubility
DMSO : 5 mg/mL (ultrasonic; adjust pH to 2 with HCl)
Smiles
O=C(C1=CN(CC2=CC=C(OC)C=C2)N=N1)N/N=C3C(NC4=C/3C=CC=C4C)=O
Molecular Formula
C20H18N6O3
Molecular Weight
390.40
References & Citations
[1]Aneja B, et al. Design and development of Isatin-triazole hydrazones as potential inhibitors of microtubule affinity-regulating kinase 4 for the therapeutic management of cell proliferation and metastasis. Eur J Med Chem. 2019 Feb 1;163:840-852.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

MARK4 inhibitor 1
CAS Number2271081-58-2
PubChem CID138454765
IUPAC NameN-[(2-hydroxy-7-methyl-1H-indol-3-yl)imino]-1-[(4-methoxyphenyl)methyl]triazole-4-carboxamide
Molecular FormulaC20H18N6O3
Molecular Weight390.4
XLogP3.7
Topological Polar Surface Area118
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Heavy Atom Count29
Formal Charge0
Complexity597
SMILES
CC1=C2C(=CC=C1)C(=C(N2)O)N=NC(=O)C3=CN(N=N3)CC4=CC=C(C=C4)OC
InChI
InChI=1S/C20H18N6O3/c1-12-4-3-5-15-17(12)21-20(28)18(15)23-24-19(27)16-11-26(25-22-16)10-13-6-8-14(29-2)9-7-13/h3-9,11,21,28H,10H2,1-2H3
InChIKey
KACGMLSYPGROFF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of MARK4 inhibitor 1
CAS: 2271081-58-2
CID: 138454765
Formula: C20H18N6O3
MW: 390.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight390.4
XLogP33.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass390.14403846
Monoisotopic Mass390.14403846
Topological Polar Surface Area118 Ų
Heavy Atom Count29
Formal Charge0
Complexity597
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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T81860-01MARK4 inhibitor 4
T11947-01MARK4 inhibitor 1
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A18695-100MARK4 inhibitor 1 100mg
A18695-10MARK4 inhibitor 1 10mg
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A18695-50MARK4 inhibitor 1 50mg
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A18695-5MARK4 inhibitor 1 5mg

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