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MARK4 inhibitor 1

CAT: 0804-HY-114317-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114317-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MARK4 inhibitor 1 is a potent and selective microtubule affinity-regulating kinase 4 (MARK4) inhibitor, with an IC50 of 1.54 μM. MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis[1].
CAS Number
2271081-58-2
Product Name Alternative
AZD-3355 (hydrochloride), AM152 (sodium), AZD-3355 (napadisylate)
UNSPSC
12352005
Target
AMPK; Apoptosis; MARK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mark4-inhibitor-1.html
Purity
98.29
Solubility
DMSO : 5 mg/mL (ultrasonic; adjust pH to 2 with HCl)
Smiles
O=C(C1=CN(CC2=CC=C(OC)C=C2)N=N1)N/N=C3C(NC4=C/3C=CC=C4C)=O
Molecular Formula
C20H18N6O3
Molecular Weight
390.40
References & Citations
[1]Aneja B, et al. Design and development of Isatin-triazole hydrazones as potential inhibitors of microtubule affinity-regulating kinase 4 for the therapeutic management of cell proliferation and metastasis. Eur J Med Chem. 2019 Feb 1;163:840-852.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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