MARK-IN-2

• Description :

  MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of 5 nM.

• UNSPSC :

  12352005

• Target :

  AMPK; MARK

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/MARK-IN-2.html

• Purity :

  99.75

• Solubility :

  DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C(C1=CC(C2=C3N=CC(Cl)=CN3N=C2)=C(C)S1)N[C@H]4C(F)(F)CCC[C@H]4N

• Molecular Formula :

  C18H18ClF2N5OS

• Molecular Weight :

  425.88

• References & Citations :

  [1]Sloman DL, et al. Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties. Bioorg Med Chem Lett. 2016 Sep 1;26 (17) :4362-6.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1314893-26-9]