MARK-IN-4

• Description:

  MARK-IN-4 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of 1 nM. Inhibition of microtubule affinity regulating kinase (MARK) represents a potentially attractive means of arresting neurofibrillary tangle pathology in Alzheimer's disease[1].

• UNSPSC:

  12352005

• Target:

  AMPK; MARK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/mark-in-4.html

• Concentration:

  10mM

• Purity:

  99.63

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=CC(C2=C3N=CC(C4=CN(C)N=C4)=CN3N=C2)=CS1)N[C@H]5[C@H](N)CCCC5

• Molecular Formula:

  C21H23N7OS

• Molecular Weight:

  421.52

• References & Citations:

  [1]Sloman DL, et al. Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties. Bioorg Med Chem Lett. 2016;26 (17) :4362-4366.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1990492-86-8]