Products for Research Use Only
RegisterLogin

GSK343 25mg

CAT: 0628-A13114-25Size: 25 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0628-A13114-25Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
1346704-33-3

Chemical Information

Gsk 343

GSK343 is a member of the class of indazoles that is 1-isopropyl-1H-indazole-4-carboxamide in which the nitrogen of the carboxamide group is substituted by a (6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl group and in which the indazole ring is substituted at position 6 by a 2-(4-methylpiperazin-1-yl)pyridin-4-yl group. A highly potent and selective EZH2 inhibitor (IC50 = 4 nM). It has a role as an EC 2.1.1.43 (enhancer of zeste homolog 2) inhibitor, an antineoplastic agent and an apoptosis inducer. It is a secondary carboxamide, a pyridone, an aminopyridine, a member of indazoles, a N-alkylpiperazine and a N-arylpiperazine.

CAS Number1346704-33-3
PubChem CID71268957
IUPAC NameN-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[2-(4-methylpiperazin-1-yl)-4-pyridinyl]-1-propan-2-ylindazole-4-carboxamide
Molecular FormulaC31H39N7O2
Molecular Weight541.7
XLogP4
Topological Polar Surface Area95.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count8
Heavy Atom Count40
Formal Charge0
Complexity986
SMILES
CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC(=NC=C4)N5CCN(CC5)C)C(C)C
InChI
InChI=1S/C31H39N7O2/c1-6-7-23-14-21(4)35-31(40)26(23)18-33-30(39)25-15-24(16-28-27(25)19-34-38(28)20(2)3)22-8-9-32-29(17-22)37-12-10-36(5)11-13-37/h8-9,14-17,19-20H,6-7,10-13,18H2,1-5H3,(H,33,39)(H,35,40)
InChIKey
ULNXAWLQFZMIHX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Gsk 343
CAS: 1346704-33-3
CID: 71268957
Formula: C31H39N7O2
MW: 541.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight541.7
XLogP34
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count8
Exact Mass541.31652351
Monoisotopic Mass541.31652351
Topological Polar Surface Area95.4 Ų
Heavy Atom Count40
Formal Charge0
Complexity986
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
A13114-10GSK343 10mg
A13114-1GSK343 1mg
A13114-100GSK343 100mg
A13114-50GSK343 50mg
A13114-5GSK343 5mg
A15549-25GSK503 25mg
A22068-25GSK046 25mg
A18346-25GSK963 25mg
A16311-25GSK583 25mg
A19073-25GSK547 25mg

Alternative Products

CatalogName
A3449-25GSK343
2365-1EZSolution™ GSK343

Popular Products