hMcl-1-IN-1

hMcl-1-IN-1

• UNSPSC Description: hMcl-1-IN-1 (Compound 9) is an hMcl-1 inhibitor based on His224 aryl sulfonate fluoride, with an IC50 value of 5.8 nM[1].
• Target Antigen: Bcl-2 Family
• Type: Reference compound
• Related Pathways: Apoptosis
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/hmcl-1-in-1.html
• Smiles: NC([C@H](CC1=CC=C(C=C1)OS(=O)(F)=O)NC([C@@H](NC([C@H](CC(O)=O)NC(CNC([C@@]([H])(NC([C@]2(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@](C)(CCC/C=C\CCC2)NC([C@H](C)NC([C@@]([H])(NC(C)=O)[C@H](CC)C)=O)=O)=O)CCC(N)=O)=O)CC(C)C)=O)CCCNC(N)=N)=O)C)=O)[C@H](CC)C)=O)=O)=O)CCCNC(N)=N)=O)=O
• Molecular Weight: 1577.82
• References & Citations: [1]Alboreggia G, et al. Covalent Targeting of Histidine Residues with Aryl Fluorosulfates: Application to Mcl-1 BH3 Mimetics[J]. Journal of Medicinal Chemistry, 2024.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported