hMcl-1-IN-1

• UNSPSC Description:

  hMcl-1-IN-1 (Compound 9) is an hMcl-1 inhibitor based on His224 aryl sulfonate fluoride, with an IC50 value of 5.8 nM[1].

• Target Antigen:

  Bcl-2 Family

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/hmcl-1-in-1.html

• Smiles:

  NC([C@H](CC1=CC=C(C=C1)OS(=O)(F)=O)NC([C@@H](NC([C@H](CC(O)=O)NC(CNC([C@@]([H])(NC([C@]2(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@](C)(CCC/C=C\CCC2)NC([C@H](C)NC([C@@]([H])(NC(C)=O)[C@H](CC)C)=O)=O)=O)CCC(N)=O)=O)CC(C)C)=O)CCCNC(N)=N)=O)C)=O)[C@H](CC)C)=O)=O)=O)CCCNC(N)=N)=O)=O

• Molecular Weight:

  1577.82

• References & Citations:

  [1]Alboreggia G, et al. Covalent Targeting of Histidine Residues with Aryl Fluorosulfates: Application to Mcl-1 BH3 Mimetics[J]. Journal of Medicinal Chemistry, 2024.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported