HSV-1-IN-1

• UNSPSC Description:

  HSV-1-IN-1 (compound 1b) is a drug candidate for herpes simplex virus HSV-1(IC50=0.5 nM) and HSV-2(IC50=16 nM) infection. HSV-1-IN-1 inhibits the helicase-primase complex to prevent viral replication, thereby inhibiting HSV infection[1].

• Target Antigen:

  HSV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/hsv-1-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=C(SC(N(C([C@@H]2CC3=C(C2)C=C(C=C3)C4=CC(F)=CC=C4F)=O)C)=N1)S(N)(=O)=O

• Molecular Weight:

  463.52

• References & Citations:

  [1]Gege C, et al. Replacement of sulfonamide by sulfoximine within a helicase-primase inhibitor with restricted flexibility[J]. Bioorganic & Medicinal Chemistry Letters, 2024: 129761.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported