(S) -Indoximod

(S) -Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO) (Ki: 19 μM) . (S) -Indoximod can be used for the research of cancer and neurological disease[1][2][3][4].

21339-55-9

1-Methyl-L-tryptophan; (S) -NLG-8189

12352005

H302, H315, H319, H335

Indoleamine 2,3-Dioxygenase (IDO)

Natural Products

Metabolic Enzyme/Protease

Cancer-programmed cell death

Cancer; Neurological Disease

https://www.medchemexpress.com/s-indoximod.html

99.52

DMSO : 4.81 mg/mL (ultrasonic; warming; adjust pH to 4 with HCl; heat to 60°C)

N[C@@H](CC1=CN(C)C2=CC=CC=C12)C(O)=O

C12H14N2O2

218.26

H302, H315, H319, H335

[1]Huang GL, et, al. PEG-Poly (1-Methyl-l-Tryptophan) -Based Polymeric Micelles as Enzymatically Activated Inhibitors of Indoleamine 2,3-Dioxygenase. Nanomaterials (Basel) . 2019 May 9;9 (5) :719.|[2]Liu X, et, al. 1-L-MT, an IDO inhibitor, prevented colitis-associated cancer by inducing CDC20 inhibition-mediated mitotic death of colon cancer cells. Int J Cancer. 2018 Sep 15;143 (6) :1516-1529.|[3]Rana P, et al. Comparison of fluoxetine and 1-methyl-L-tryptophan in treatment of depression-like illness in Bacillus Calmette-Guerin-induced inflammatory model of depression in mice. J Basic Clin Physiol Pharmacol. 2016 Nov 1;27 (6) :569-576. |[4]Čepcová D, et al. The protective effect of 1-methyltryptophan isomers in renal ischemia-reperfusion injury is not exclusively dependent on indolamine 2,3-dioxygenase inhibition. Biomed Pharmacother. 2021 Mar;135:111180. |[5]Jiang X, et al. Role of the indoleamine-2,3-dioxygenase/kynurenine pathway of tryptophan metabolism in behavioral alterations in a hepatic encephalopathy rat model. J Neuroinflammation. 2018 Jan 4;15 (1) :3.|[6]Oh JE, et al. 1-Methyl-L-tryptophan promotes the apoptosis of hepatic stellate cells arrested by interferon-γ by increasing the expression of IFN-γRβ, IRF-1 and FAS. Int J Mol Med. 2017 Aug;40 (2) :576-582.

Room Temperature

4°C (Powder, protect from light)

Natural Products