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Indoximod

CAT: 0804-HY-16724-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-16724-01Size:100 mg
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Description
Indoximod (1-Methyl-D-tryptophan) is an orally active indoleamine 2,3-dioxygenase (IDO) pathway inhibitor. Indoximod acts as a Trp mimetic in regulating mTOR. Indoximod is an immunometabolic adjuvant used for the research of cancer[1][2].
CAS Number
[110117-83-4]
Product Name Alternative
1-Methyl-D-tryptophan; NLG-8189
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Indoleamine 2,3-Dioxygenase (IDO)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Indoximod.html
Purity
99.85
Solubility
0.5 M NaOH : 66.67 mg/mL (ultrasonic) |DMSO : 0.55 mg/mL (ultrasonic; warming) |H2O : 5 mg/mL (ultrasonic; adjust pH to 2 with HCl)
Smiles
N[C@H](CC1=CN(C)C2=CC=CC=C12)C(O)=O
Molecular Formula
C12H14N2O2
Molecular Weight
218.26
Precautions
H302, H315, H319, H335
References & Citations
[1]Hou DY, et al. Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophancorrelates with antitumor responses. Cancer Res. 2007 Jan 15;67 (2) :792-801.|[2]Metz R, et al. IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan. Oncoimmunology. 2012;1 (9) :1460-1468.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
IDO

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