Indoximod

• UNSPSC Description:

  Indoximod (1-Methyl-D-tryptophan) is an orally active indoleamine 2,3-dioxygenase (IDO) pathway inhibitor. Indoximod acts as a Trp mimetic in regulating mTOR. Indoximod is an immunometabolic adjuvant used for the research of cancer[1][2].

• Target Antigen:

  Indoleamine 2,3-Dioxygenase (IDO)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Indoximod.html

• Solubility:

  DMSO : 0.55 mg/mL (ultrasonic;warming)|H2O : 5 mg/mL (ultrasonic;adjust pH to 2 with HCl)

• Smiles:

  N[C@H](CC1=CN(C)C2=CC=CC=C12)C(O)=O

• Molecular Weight:

  218.256

• References & Citations:

  [1]Hou DY, et al. Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophancorrelates with antitumor responses. Cancer Res. 2007 Jan 15;67(2):792-801.|[2]Metz R, et al. IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan. Oncoimmunology. 2012;1(9):1460-1468.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  Phase 2

• CAS Number:

  110117-83-4