(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH

(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH

• Product Name Alternative: VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH
• CAS Number: 2086301-47-3
• UNSPSC Description: (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH) is a E3 ligase ligand-linker conjugate that contains on one end a VHL ligand. (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH is used in PROTAC technology[1].
• Target Antigen: E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: PROTAC
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/s-r-s-ahpc-boc-trans-3-aminocyclobutanol-pip-ch2cooh.html
• Purity: 99.31
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(CN1CCC(O[C@H]2C[C@H](NC(OC(C)(C)C)=O)C2)CC1)N[C@H](C(N([C@H](C(N[C@@H](C)C3=CC=C(C=C3)C4=C(C)N=CS4)=O)C5)C[C@@H]5O)=O)C(C)(C)C
• Molecular Weight: 754.98
• References & Citations: [1]Yimin Qian, et al. Compounds and methods for the targeted degradation of bromodomain-containing proteins. WO2017030814A1.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-991.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture and light)
• Clinical Information: No Development Reported