(S,R,S)-AHPC-acetyl-azetidine-PIP-boc

(S,R,S)-AHPC-acetyl-azetidine-PIP-boc

• UNSPSC Description: (S,R,S)-AHPC-acetyl-azetidine-PIP-boc is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S,R,S)-AHPC-acetyl-azetidine-PIP-boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.
• Target Antigen: E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/e3-ligase-ligand-linker-conjugate-25.html
• Solubility: 10 mM in DMSO
• Smiles: O=C([C@H]1N(C[C@@H](C1)O)C([C@H](C(C)(C)C)NC(CN2CC(C2)N3CCN(CC3)C(OC(C)(C)C)=O)=O)=O)NCC(C=C4)=CC=C4C(SC=N5)=C5C
• Molecular Weight: 711.91
• References & Citations: [1]Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation. Cancer Res. 2019 Jul 16. pii: canres.1236.2019.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported