(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH

• Product Name Alternative:

  VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH

• UNSPSC Description:

  (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH) is a E3 ligase ligand-linker conjugate that contains on one end a VHL ligand. (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH is used in PROTAC technology[1].

• Target Antigen:

  E3 Ligase Ligand-Linker Conjugates

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/s-r-s-ahpc-boc-trans-3-aminocyclobutanol-pip-ch2cooh.html

• Purity:

  99.31

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(CN1CCC(O[C@H]2C[C@H](NC(OC(C)(C)C)=O)C2)CC1)N[C@H](C(N([C@H](C(N[C@@H](C)C3=CC=C(C=C3)C4=C(C)N=CS4)=O)C5)C[C@@H]5O)=O)C(C)(C)C

• Molecular Weight:

  754.98

• References & Citations:

  [1]Yimin Qian, et al. Compounds and methods for the targeted degradation of bromodomain-containing proteins. WO2017030814A1.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-991.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture and light)

• Clinical Information:

  No Development Reported

• CAS Number:

  2086301-47-3