Products for Research Use Only

Rasagiline mesylate

CAT: 0400-SIH-577-250MGSize: 250 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-577-250MGSize:250 mg
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Background
Potent, irreversible monoamine oxidase (MAO) inhibitor selective for MAO-B (IC50=4.43 nM) over MAO-A (IC50=412 nM) (1). Parkinson’s disease therapeutic (2). Displays neuroprotective and neurorestorative properties in a Parkinson’s disease zebrafish model (3). Prevents α-synuclein-induced dopaminergic neuronal death and rescues TrkB neurotrophic signaling (4). Enhances BDNF levels and is neuroprotective in Parkinson’s disease models (5).
Description
MAO inhibitor
CAS Number
161735-79-1
Product Name Alternative
(1R) -2,3-Dihydro-N-2-propynyl-1H-inden-1-amine, methanesulfonate; TVP-1012; Azilect
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Neuroscience | Neurodegeneration | Parkinson's Disease | Synuclein
Purity
>99% (HPLC) ; NMR (Conforms)
Weight
0.005
Format
White crystalline powder
Solubility
May be dissolved in DMSO (50 mg/ml); or water (50 mg/ml); Ethanol (30 mg/ml)
Molecular Formula
C12H13N • CH3SO3H
Molecular Weight
267.3
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. MBH Youdim et al. Br. J. Pharmacol. 2001 132:500 2. E Cereda et al. J. Neurol. 2017 264:1254 3. A Cronin and M Grealy Neuroscience 2017 367:34 4. SS Kang et al. Proc. Natl. Acad. Sci. USA 2017 114:10773 5. A Ledreux et al. Brain Res. 2016 1631:34