Rasagiline mesylate

Rasagiline mesylate

• Background: Potent, irreversible monoamine oxidase (MAO) inhibitor selective for MAO-B (IC50=4.43 nM) over MAO-A (IC50=412 nM) (1). Parkinson’s disease therapeutic (2). Displays neuroprotective and neurorestorative properties in a Parkinson’s disease zebrafish model (3). Prevents α-synuclein-induced dopaminergic neuronal death and rescues TrkB neurotrophic signaling (4). Enhances BDNF levels and is neuroprotective in Parkinson’s disease models (5).
• Description: MAO inhibitor
• Product Name Alternative: (1R)-2,3-Dihydro-N-2-propynyl-1H-inden-1-amine, methanesulfonate; TVP-1012; Azilect
• CAS Number: 161735-79-1
• UNSPSC: 41116105
• Source: Synthetic
• Purity: >99% (HPLC); NMR (Conforms)
• Weight: 0.005
• Format: White crystalline powder
• Solubility: May be dissolved in DMSO (50 mg/ml); or water (50 mg/ml); Ethanol (30 mg/ml)
• Molecular Formula: C12H13N • CH3SO3H
• Molecular Weight: 267.3
• Precautions: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
• References & Citations: 1. MBH Youdim et al. Br. J. Pharmacol. 2001 132:500 2. E Cereda et al. J. Neurol. 2017 264:1254 3. A Cronin and M Grealy Neuroscience 2017 367:34 4. SS Kang et al. Proc. Natl. Acad. Sci. USA 2017 114:10773 5. A Ledreux et al. Brain Res. 2016 1631:34