Camostat mesylate

CAT: 0400-SIH-585-10MGSize: 10 mgDry Ice: NoHazardous: No
CAT#:0400-SIH-585-10MGSize:10 mg
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Background
Camostat mesylate is an orally active protease inhibitor. It inhibits the serine protease TMPRSS2 and partially blocks entry of SARS-Cov-2 (Covid-19) into lung cells and Human coronavirus NL63 into HeLa cells. It has also been used in some cancer treatments, against viral infections, and for inhibiting fibrosis in liver, kidney disease and pancreatitis.
Description
Serine protease inhibitor
CAS Number
59721-29-8
Product Name Alternative
4-[[4-[ (Aminoiminomethyl) amino]benzoyl]oxy]benzeneacetic acid 2- (dimethylamino) -2-oxoethyl ester methanesulfonate; FOY 305; FOY-S 980; Foipan mesylate
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Cell Signaling
Purity
>98% (HPLC) ; NMR (Conforms)
Weight
0.005
Format
Off-white powder
Solubility
May be dissolved in DMSO (50 mg/mL) or Water (50mg/mL)
Molecular Formula
C20H22N4O5·CH3SO3H
Molecular Weight
494.5
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Okuno M., et al. (2002). Front Biosci. 7 (4): d204-218. 2. Hsieh H. P., Hsu, J. T. (2007). Current Pharmaceutical Design. 13 (34): 3531–3542. 3. Kitamura K., Tomita K. (2012). Clinical and Experimental Nephrology. 16 (1): 44–48. 4. Kawase M., Shirato K., van der Hoek L., Taguchi F., Matsuyama S. (2012) J Virol. 86(12): 6537-6545. 5.. Hoffman M., et al. (2020) Cell: https://doi.org/10.1016/j.cell.2020.02.052

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