C-646

• Background:

  Potent and selective inhibitor of the histone acetyl transferase p300/CBP (Ki=400 nM ). Induces apoptosis in prostate cancer cells. Enhances fear extinction memory and synaptic plasticity in mice. Promotes tau deacetylation reducing levels of pathogenic p-tau. Cell permeable.

• Description:

  HAT inhibitor

• Product Name Alternative:

  4-[4-[[5- (4,5-Dimethyl-2-nitrophenyl) -2-furanyl]methylene]- 4,5-dihydro-3-methyl-5-oxo-1Hpyrazol- 1-yl]benzoic acid

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Epigenetics and Nuclear Signaling

• Purity:

  >98% (TLC), NMR conforms

• Weight:

  0.005

• Format:

  Orange Solid

• Solubility:

  Soluble in 10 mg/ml DMSO

• Molecular Formula:

  C24H19N3O6

• Molecular Weight:

  445.4

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Bowers E.M., et al. (2010) Chem. Biol. 17: 471. 2. Santer F.R., et al. (2011) Mol. Cancer Ther. 10: 1644. 3. Marek R., et al. (2011) J. Neurosci. 31: 7486. 4. Min S.W., et al. (2010) Neuron 67: 953.

• CAS Number:

  328968-36-1