Mitomycin C

• Background:

  The mitomycins are a family of aziridine containing natural products. Mitomycin C is a chemotherapeutic agent because of its mechanism of potent DNA crosslinker, reductive activation followed by two N-alklyations. Both alkylations are sequence specific for a guanine nucleoside in the sequence 5'-CpG-3' (1).

• Description:

  DNA synthesis inhibitor

• Product Name Alternative:

  [ (1aS,8S,8aR,8bS) -6-Amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate, Ametycine

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis

• Purity:

  >99% (TLC) ; NMR (Conforms)

• Weight:

  0.05

• Format:

  Dark Purple Crystalline Solid

• Solubility:

  May be dissolved in DMSO (15mg/mL); or water (1mg/mL, warm)

• Molecular Formula:

  C15H18N4O5

• Molecular Weight:

  334.33

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Tomasz M. (1995). Chem and Biol. 2(9): 575-579.

• CAS Number:

  50-07-7