Mitomycin C

• Background :

  The mitomycins are a family of aziridine containing natural products. Mitomycin C is a chemotherapeutic agent because of its mechanism of potent DNA crosslinker, reductive activation followed by two N-alklyations. Both alkylations are sequence specific for a guanine nucleoside in the sequence 5'-CpG-3' (1).

• Description :

  DNA synthesis inhibitor

• Product Name Alternative :

  [ (1aS,8S,8aR,8bS) -6-Amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate, Ametycine

• UNSPSC :

  41116105

• Type :

  Inhibitor

• Source :

  Synthetic

• Field of Research :

  Cancer | Apoptosis

• Purity :

  >99% (TLC) ; NMR (Conforms)

• Weight :

  0.05

• Format :

  Dark Purple Crystalline Solid

• Solubility :

  May be dissolved in DMSO (15mg/mL); or water (1mg/mL, warm)

• Molecular Formula :

  C15H18N4O5

• Molecular Weight :

  334.33

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. Tomasz M. (1995). Chem and Biol. 2(9): 575-579.

• CAS Number :

  50-07-7