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Mitomycin C

CAT: 0400-SIH-246-50MGSize: 50 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-246-50MGSize:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The mitomycins are a family of aziridine containing natural products. Mitomycin C is a chemotherapeutic agent because of its mechanism of potent DNA crosslinker, reductive activation followed by two N-alklyations. Both alkylations are sequence specific for a guanine nucleoside in the sequence 5'-CpG-3' (1).
Description
DNA synthesis inhibitor
CAS Number
50-07-7
Product Name Alternative
[ (1aS,8S,8aR,8bS) -6-Amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate, Ametycine
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis
Purity
>99% (TLC) ; NMR (Conforms)
Weight
0.05
Format
Dark Purple Crystalline Solid
Solubility
May be dissolved in DMSO (15mg/mL); or water (1mg/mL, warm)
Molecular Formula
C15H18N4O5
Molecular Weight
334.33
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Tomasz M. (1995). Chem and Biol. 2(9): 575-579.

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