C-Dim 12

• Background:

  C-DIM 12 is a nurr1 activator that inhibits bladder cancer growth (1,2). It also inhibits NF-κB and cytokine expression in microglial cells by stabilizing nuclear corepressor proteins, which reduces binding of p65 to inflammatory gene promoters (3). It displays neuroprotective activity in a mouse Parkinson's disease models (4).

• Description:

  Displays neuroprotective activity in a mouse model of progressive neurodegeneration

• Product Name Alternative:

  3,3'-[ (4-Chlorophenyl) methylene]bis[1H-indole]

• UNSPSC:

  41116105

• Type:

  Activator

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Epigenetics and Nuclear Signaling | Nuclear Signaling Pathways | NFkB Pathway | Neuroscience | Neurodegeneration | Parkinson's Disease

• Purity:

  >98% (TLC) ; NMR (Conforms)

• Weight:

  0.005

• Format:

  Orange powder

• Solubility:

  May be dissolved in DMSO (35 mg/ml); or ethanol (35 mg/ml)

• Molecular Formula:

  C23H17ClN2

• Molecular Weight:

  356.9

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1.Inamoto T., et al. (2008) Mol. Cancer Ther. 7:3825 2.Li X., et al. (2012) Biochem. Pharmacol. 83:1445 3.De Miranda B.R.,et al. (2015) Mol. Pharmacol. 87:1021 4.De Miranda B.R., et al. (2013) J. Pharmacol. Exp. Ther. 345:125

• CAS Number:

  178946-89-9