Apicidin

• Background:

  Cyclopeptide inhibitor of histone deactylases (HDACs). Inhibits HeLa cell proliferation (IC50=50-100 nM) and induces reversible transcriptional activation of p21 (WAF1). Decreases HIF1α protein levels and transcriptional activity in human and mouse tumor cell lines. Cell permeable.

• Description:

  HDAC inhibitor

• Product Name Alternative:

  (3S,6S,9S,15aR) -9-[ (2S) -2-Butanyl]-6-[ (1-methoxy-1H-indol-3-yl) methyl]-3- (6-oxooctyl) octahydro-2H-pyrido[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10 (3H,12H) -tetrone; Cyclo (N-O-methyl-L-tryptophanyl-L Lisoleucinyl-Dpipecolinyl-L-2-amino-8-oxodecanoyl)

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Epigenetics and Nuclear Signaling | Cancer

• Purity:

  >98% (HPLC) ; NMR (conforms)

• Weight:

  0.001

• Format:

  White Solid

• Solubility:

  Soluble in 10 mg/ml DMSO or 100% Ethanol

• Molecular Formula:

  C34H49N5O6

• Molecular Weight:

  623.8

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Darkin-Rattray S.J., et al. (1996) Proc. Natl. Acad. Sci. USA. 93: 13143. 2. Han J.W., et al. (2000) Cancer Res. 60: 6068. 3. Kim S.H., et al. (2007) Oncol. Rep. 17: 647.

• CAS Number:

  183506-66-3