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Apicidin

CAT: 0400-SIH-346-5MGSize: 5 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-346-5MGSize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cyclopeptide inhibitor of histone deactylases (HDACs). Inhibits HeLa cell proliferation (IC50=50-100 nM) and induces reversible transcriptional activation of p21 (WAF1). Decreases HIF1α protein levels and transcriptional activity in human and mouse tumor cell lines. Cell permeable.
Description
HDAC inhibitor
CAS Number
183506-66-3
Product Name Alternative
(3S,6S,9S,15aR) -9-[ (2S) -2-Butanyl]-6-[ (1-methoxy-1H-indol-3-yl) methyl]-3- (6-oxooctyl) octahydro-2H-pyrido[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10 (3H,12H) -tetrone; Cyclo (N-O-methyl-L-tryptophanyl-L Lisoleucinyl-Dpipecolinyl-L-2-amino-8-oxodecanoyl)
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Epigenetics and Nuclear Signaling | Cancer
Purity
>98% (HPLC) ; NMR (conforms)
Weight
0.005
Format
White Solid
Solubility
Soluble in 10 mg/ml DMSO or 100% Ethanol
Molecular Formula
C34H49N5O6
Molecular Weight
623.8
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Darkin-Rattray S.J., et al. (1996) Proc. Natl. Acad. Sci. USA. 93: 13143. 2. Han J.W., et al. (2000) Cancer Res. 60: 6068. 3. Kim S.H., et al. (2007) Oncol. Rep. 17: 647.

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CatalogName
TBZ0040Apicidin

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