RELA antibody

Nuclear factor k B (NF-kB) is a sequence-specific DNA-binding protein complex which regulates the expression of viral genomes, including the human immunodeficiency virus, and a variety of cellular genes, particularly those involved in immune and inflammatory responses. The members of the NF-Kb family in mammalian cells include the proto-oncogene c-Rel, p50/p105 (NFkB1), p65 (RelA), p52/p100 (NFkB2), and RelB. All of these proteins share a conserved 300-amino acid region known as the Rel homology domain which is responsible for DNA binding, dimerization, and nuclear translocation of NF-Kb. The p65 subunit is a major component of NF-Kb complexes and is responsible for trans-activation. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. It associates with chromatin at the NF-kappa-B promoter region via association with DDX1.

Transcription factor p65|Nuclear factor NF-kappa-B p65 subunit|Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3|RELA|NFKB3

5970

Q04206

Human

V-rel reticuloendotheliosis viral oncogene homolog A (avian)

RELA

ELISA, WB, IHC

Metabolism, Immunology, Cancer, Stem Cells, Cell Division and Proliferation

Protein A+G purification

WB: 1:500-1:2000; IHC: 1:50-1:200

≥95% as determined by SDS-PAGE

Liquid

65 kDa

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

6G6

ELISA, WB, IHC