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Diethyl-Lodoxamide

CAT: 0804-HY-167706-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-167706-01Size:1 mg
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Description
Diethyl-Lodoxamide is a highly potent GPR35 agonist with potential to inhibit inflammatory bowel disease. Diethyl-Lodoxamide activates GPR35 in humans, mice and rats, showing similar EC50 values. Diethyl-Lodoxamide can alleviate the clinical symptoms of DSS-induced inflammatory bowel disease in mouse models, and the effect is better than the traditional drug 5-ASA. The pharmaceutical properties of Diethyl-Lodoxamide have been optimized to better meet the requirements of drug design[1].
CAS Number
53882-13-6
UNSPSC
12352005
Target
GPR35
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/diethyl-lodoxamide.html
Smiles
N#CC1=CC(NC(C(OCC)=O)=O)=C(Cl)C(NC(C(OCC)=O)=O)=C1
Molecular Formula
C15H14ClN3O6
Molecular Weight
367.74
References & Citations
[1]Discovery of a novel GPR35 agonist with high and equipotent species potency for oral treatment of IBD
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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