Lodoxamide

• Description:

  Lodoxamide (U-42585E free acid) is an antiallergic compound acting as a mast-cell stabilizer for the treatment of asthma and allergic conjunctivitis.

• Product Name Alternative:

  U-42585E (free acid)

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H312, H332

• Target:

  Histamine Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/Lodoxamide.html

• Purity:

  98.07

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  OC(C(NC1=C(Cl)C(NC(C(O)=O)=O)=CC(C#N)=C1)=O)=O

• Molecular Formula:

  C11H6ClN3O6

• Molecular Weight:

  311.63

• Precautions:

  H302, H312, H332

• References & Citations:

  [1]Watt GD, et al. Protective effect opf lodoxamide tromethamine on allergen inhalation challenge. J Allergy Clin Immunol. 1980 Oct;66 (4) :286-94.|[2]Capron M, et al. Inhibitory effects of lodoxamide on eosinophil activation. Int Arch Allergy Immunol. 1998 Jun;116 (2) :140-6.|[3]Barr ML, et al. Addition of a mast cell stabilizing compound to organ preservation solutions decreases lung reperfusion injury. J Thorac Cardiovasc Surg. 1998 Mar;115 (3) :631-6; discussion 636-7.|[4]Mann JS, et al. Inhaled lodoxamide tromethamine in the treatment of perennial asthma: a double-blind placebo-controlled study. J Allergy Clin Immunol. 1985 Jul;76 (1) :83-90.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  [53882-12-5]