Products for Research Use Only
RegisterLogin

RAPTA-C

CAT: 0804-HY-130326-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-130326-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
RAPTA-C (Ru (η6-p-cymene) Cl2 (pta) ) acts as an anti-cancer and anti-angiogenic agent. RAPTA-C exhibits anti-metastatic, anti-angiogenic, and anti-tumoral activities through protein and histone-deoxyribonucleic acid alterations. RAPTA-C exhibits cell growth inhibition by triggering G (2) /M phase arrest in cancer cells. RAPTA-C also enhances the levels of p53 and triggers the mitochondrial Apoptotic pathway, resulting in cytochrome C release and caspase-9 activation. RAPTA-C reduces the growth of tumors with the inhibition of angiogenesis in a ovarian carcinoma model[1][2][3].
CAS Number
372948-28-2
Product Name Alternative
Ru (η6-p-cymene) Cl2 (pta)
UNSPSC
12352005
Target
Apoptosis; Caspase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/rapta-c.html
Purity
99.30
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC12=C3[Ru+2]145(C6=C52)(P78C[N@@](C9)C[N@@](C[N@@]9C8)C7)([Cl-])([Cl-])C6(C(C)C)=C43
Molecular Formula
C16H23Cl2N3PRu
Molecular Weight
460.32
References & Citations
[1]Rausch M, et al. Recent considerations in the application of RAPTA‐C for cancer treatment and perspectives for its combination with immunotherapies[J]. Advanced Therapeutics, 2019, 2 (9) : 1900042.|[2]Weiss A, et al. In vivo anti-tumor activity of the organometallic ruthenium (II) -arene complex [Ru (η 6-p-cymene) Cl 2 (pta) ] (RAPTA-C) in human ovarian and colorectal carcinomas[J]. Chemical Science, 2014, 5 (12) : 4742-4748.|[3]Chatterjee S, et al. The ruthenium (II) -arene compound RAPTA-C induces apoptosis in EAC cells through mitochondrial and p53-JNK pathways. J Biol Inorg Chem. 2008 Sep;13 (7) :1149-55.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-140336-01C-NH-Boc-C-Bis- (C-PEG1-Boc)
HY-138383CHO-C-PEG2-C-CHO
HY-168132Thalidomide-NH-C-C6H10-C-acid
HY-161974Adamantan-C-amide-PEG2-C-Br
HY-W382140-014′-C-Fluoro-2′-C-methyluridine
HY-178831Azacyclohexane-C-piperazine-C (OCH3) 2
HY-161210Thalidomide-azetidine-C-PIP-C-boc
HY-P11336Oscillamide C
HY-P11086C (R3W4V)
HY-N5162Arborcandin C

Alternative Products

CatalogName
T34262-01RAPTA-C
N2146-25BNeuroendocrine Specific Protein C (NSP-C Rtn C Reticulon C)
GTR18404846-01Antibody to C. trachomatis, C. pneumoniae & C. psittaci
Oneq-V334-01C. jejuni and C. coli
053489Cys-C (Cystatin C)
B2011295C-Phycocyanin (C-PC)
sc-514526Spi-C (C-2)
sc-271243C-Fos (C-10)
sc-166088HLA-C (C-8)
sc-48396C-Yes (C-4)

Popular Products