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Lavendustin C

CAT: 0804-HY-W013857-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W013857-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lavendustin C is a potent Ca2+ calmodulin-dependent kinase II (CaMK II) inhibitor with an IC50 of 0.2 μM. Lavendustin C inhibits EGFR-associated tyrosine kinase (IC50=0.012 μM) and pp60c-src (+) kinase (IC50=0.5 μM) [1][2].
CAS Number
125697-93-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CaMK; EGFR; Src
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lavendustin-c.html
Purity
98.32
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC(NCC2=CC(O)=CC=C2O)=CC=C1O
Molecular Formula
C14H13NO5
Molecular Weight
275.26
Precautions
H302, H315, H319, H335
References & Citations
[1]T Onoda, et al.Isolation of a Novel Tyrosine Kinase Inhibitor, Lavendustin A, From Streptomyces Griseolavendus. J Nat Prod. Nov-Dec 1989;52 (6) :1252-7.|[2]T J O'Dell, et al.Long-term Potentiation in the Hippocampus Is Blocked by Tyrosine Kinase Inhibitors. Nature. 1991 Oct 10;353 (6344) :558-60.|[3]H M Burt, et al. Inhibition of Crystal-Induced Neutrophil Activation by a Protein Tyrosine Kinase Inhibitor. J Leukoc Biol. 1994 Jan;55 (1) :112-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CaMK II; EGFR/ErbB1/HER1

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