Lavendustin C

Lavendustin C

• CAS Number: 125697-93-0
• UNSPSC Description: Lavendustin C is a potent Ca2+ calmodulin-dependent kinase II (CaMK II) inhibitor with an IC50 of 0.2 μM. Lavendustin C inhibits EGFR-associated tyrosine kinase (IC50=0.012 μM) and pp60c-src(+) kinase (IC50=0.5 μM) [1][2].
• Target Antigen: CaMK; EGFR; Src
• Type: Reference compound
• Related Pathways: JAK/STAT Signaling;Neuronal Signaling;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/lavendustin-c.html
• Purity: 98.32
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(O)C1=CC(NCC2=CC(O)=CC=C2O)=CC=C1O
• Molecular Weight: 275.26
• References & Citations: [1]T Onoda, et al.Isolation of a Novel Tyrosine Kinase Inhibitor, Lavendustin A, From Streptomyces Griseolavendus. J Nat Prod. Nov-Dec 1989;52(6):1252-7.|[2]T J O'Dell, et al.Long-term Potentiation in the Hippocampus Is Blocked by Tyrosine Kinase Inhibitors. Nature. 1991 Oct 10;353(6344):558-60.|[3]H M Burt, et al. Inhibition of Crystal-Induced Neutrophil Activation by a Protein Tyrosine Kinase Inhibitor. J Leukoc Biol. 1994 Jan;55(1):112-9.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported