ENaC gamma Antibody

CAT: 0400-SPC-405DSize: 100 µgDry Ice: NoHazardous: No
CAT#:0400-SPC-405DSize:100 µg
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Background
The gamma subunit of the epithelial sodium channel (ENaCγ) is a vital component of the heterotrimeric ENaC complex, which regulates sodium ion transport across epithelial surfaces. While ENaCγ is traditionally associated with fluid and electrolyte balance in organs such as the kidney, lung, and colon, its emerging role in the nervous system is gaining attention in neurodegenerative disease research. ENaCγ, in conjunction with the beta subunit, is essential for efficient fluid absorption in distal lung epithelia, particularly under edematous conditions. This functional synergy suggests a broader role in maintaining tissue homeostasis under stress. In the retina, differential expression of ENaC subunits—including ENaCγ—has been observed in models of ocular hypertension, implicating ENaCγ in neuroprotective responses to elevated intraocular pressure, a key risk factor in glaucoma. Recent insights propose that ENaCγ may influence neural cell volume regulation, glial activation, and blood-brain barrier integrity—processes that are disrupted in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and multiple sclerosis. Its mechanosensitive properties and role in sodium flux position ENaCγ as a potential modulator of neuroinflammation and ionic imbalance in the central nervous system. As the field of neuroionics expands, ENaCγ is emerging as a promising target for therapeutic development and biomarker discovery in neurodegeneration, bridging epithelial physiology and neural resilience.
Description
Rabbit Anti-Rat ENaC gamma Polyclonal
CAS Number
9007-83-4
Specifications
Detects ~83kDa.
Product Name Alternative
SCNN1G, Epithelial Sodium Channel gamma, Amiloride sensitive epithelial sodium channel gamma subunit, Amiloride sensitive sodium channel subunit gamma, Amiloride-sensitive sodium channel subunit gamma, BESC3, ENaC gamma subunit, ENaCG, ENaCgamma, Epithelial Na (+) channel subunit gamma, Epithelial Na+ channel subunit gamma, Gamma ENaC, Gamma NaCH, Gamma-ENaC, Gamma-NaCH, Nonvoltage gated sodium channel 1 subunit gamma, Nonvoltage-gated sodium channel 1 subunit gamma, PHA 1, PHA1, SCNEG, SCNN 1G, SCNNG_HUMAN, Sodium channel non voltage gated 1 gamma subunit, Sodium channel nonvoltage gated 1 gamma
UNSPSC
12352203
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Gene ID
24768
Swiss Prot
P37091
Accession Number
NP_058742
Cellular Locus
Apical Cell Membrane
Host
Rabbit
Species Reactivity
Rat, Mouse, Xenopus, Hamster, Human
Immunogen
Produced against the C-terminal tail (amino acids 629-650) of rat gamma ENaC (antibody designation L550)
Target
ENaC
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal
Applications
WB | IHC | ICC/IF
Validated Applications
WB, IHC, ICC/IF
Field of Research
Neuroscience | Neurotransmission | Ion Channels | Sodium Channels | Epithelial Sodium Channels (ENaC)
Purification
Protein A Purified
Detection Range
1 µg/ml of SPC-405 was sufficient for detection of gamma-ENaC in 20 µg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Concentration
1 mg/ml
Dilution
WB (1:1000), IHC (1:100) ; optimal dilutions for assays should be determined by the user.
Weight
0.1
Buffer
PBS, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Kakizoe Y., et al. (2009) J Hypertens. 27 (8) : 1679-1689. 2. Gu Y. (2008) J Cell Physiol. 216 (2) :453-457. 3. Bruns J.B. (2003) Am J Physiol Renal Physiol. 285 (4) : F600-F609. 4. Mauro T., et al. (2002) J Invest Dermatol. 118 (4) : 589-594. 5. Elias N., et al. (2007) Am J Physiol Lung Cell Mol Physiol. 293 (3) : L537-45. 6. Dyka F.M., May C.A. and Enz R. (2005) J Neurochem. 94 (1) : 120-128.
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
-20ºC
Specificity
Detects ~83kDa.
Species
Rat | Mouse | African clawed frog (Xenopus laevis) | Hamster | Human
Location
Apical Cell Membrane
Immunogen Species
Rat

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