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ENaC gamma Antibody (APC)

CAT: 0013-GTR18029452Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18029452Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rabbit polyclonal to ENaC Gamma (APC) . The Epithelial Sodium Channel (ENaC) is a membrane ion channel permeable to Na+ ions. It is located in the apical plasma membrane of epithelia in the kidneys, lung, colon, and other tissues where it plays a role in trans epithelial Na+-ion transport. Specifically Na+ transport via ENaC occurs across many epithelial surfaces, and plays a key role in regulating salt and water absorption. ENaCs are composed of three structurally related subunits that form a tetrameric channel, alpha, beta , and gamma. The expression of its alpha and beta subunits is enhanced as keratinocytes differentiate. The beta and gamma-ENaC subunits are essential for edema fluid to exert its maximal effect on net fluid absorption by distal lung epithelia (5) . And it has been concluded that the subunits are differentially expressed in the retina of mice with ocular hypertension, therefore the up-regulation of alpha-ENaC proteins could serve as a protection mechanism against elevated intraocular pressure..
Product Name Alternative
SCNN1G, Epithelial Sodium Channel gamma, Amiloride sensitive epithelial sodium channel gamma subunit, Amiloride sensitive sodium channel subunit gamma, Amiloride-sensitive sodium channel subunit gamma, BESC3, ENaC gamma subunit, ENaCG, ENaCgamma, Epithelial Na (+) channel subunit gamma, Epithelial Na+ channel subunit gamma, Gamma ENaC, Gamma NaCH, Gamma-ENaC, Gamma-NaCH, Nonvoltage gated sodium channel 1 subunit gamma, Nonvoltage-gated sodium channel 1 subunit gamma, PHA 1, PHA1, SCNEG, SCNN 1G, SCNNG_HUMAN, Sodium channel non voltage gated 1 gamma subunit, Sodium channel nonvoltage gated 1 gamma
UniProt
P37091
Reactivity
Frog, Hamster, Human, Mouse, Rat
Immunogen
Produced against the C-terminal tail (amino acids 629-650) of rat gamma ENaC (antibody designation L550)
Target
ENaC gamma
Clonality
Polyclonal
Conjugation
APC
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purification
Protein A Purified
Concentration
1 mg/ml
Dilution
WB (1:1000), IHC (1:100)
Molecular Weight
83kDa
Storage Conditions
Conjugated antibodies should be stored according to the product label
Notes
For research use only.
Applications Notes
1 μg/ml was sufficient for detection of gamma-ENaC in 20 μg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Tested Applications
ICC, IF, IHC, WB
NCBI Accession Number
NP_058742
Host or Source
Rabbit
Preservative
95.46mM Phosphate, 2.48mM MES and 2mM EDTA
Entrez
24768

UniProtKB · P37091

Epithelial sodium channel subunit gamma

SCNNG_RAT · Rattus norvegicus

View on UniProt ↗
Primary accession
P37091
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Scnn1g
Protein existence
1: Evidence at protein level
Organism
Rattus norvegicus (Rat)
Taxonomy ID
10116
Alternative names
Gamma-ENaC, pithelial Na(+) channel subunit gamma
EC number
—
Processing
—
Secondary accessions
—
Protein keywords

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinPhosphoproteinUbl conjugation

Molecular function

Ion channelSodium channel

Biological process

Ion transportSodium transportTransport

Technical term

Reference proteome

Ligand

Sodium

Domain

TransmembraneTransmembrane helix

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