ENaC alpha Antibody

CAT: 0400-SPC-403SSize: 12 µgDry Ice: NoHazardous: No
CAT#:0400-SPC-403SSize:12 µg
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Background
The epithelial sodium channel alpha subunit (ENaCα) is a key component of the heterotrimeric ENaC complex, which regulates sodium ion transport across epithelial membranes. While traditionally studied in renal, pulmonary, and gastrointestinal systems, emerging evidence highlights ENaCα’s relevance in the central nervous system and neurodegenerative disease. ENaCα modulates ionic homeostasis and fluid balance in neural tissues, contributing to neuroprotection under stress conditions. In models of ocular hypertension, upregulation of ENaCα in retinal tissues suggests a compensatory mechanism to counteract elevated intraocular pressure, a known risk factor for glaucoma. Additionally, ENaCα expression is dynamically regulated during keratinocyte differentiation, indicating its broader role in cellular stress responses and tissue remodeling. These findings point to ENaCα as a potential modulator of neuroinflammation and glial activation—processes central to neurodegenerative pathologies such as Alzheimer’s disease and multiple sclerosis. As interest grows in ion channel dysfunction in neurodegeneration, ENaCα is gaining attention as a novel target for therapeutic intervention. Its role in maintaining ionic equilibrium and responding to mechanical and osmotic stress positions it at the intersection of neuroscience, neuroprotection, and precision medicine.
Description
Rabbit Anti-Rat ENaC alpha Polyclonal
CAS Number
9007-83-4
Specifications
Detects ~85kDa.
Product Name Alternative
Alpha ENaC, Alpha ENaC 2, Alpha NaCH, Alpha-ENaC, Amiloride sensitive epithelial sodium channel alpha subunit, Amiloride sensitive sodium channel subunit alpha, Amiloride-sensitive sodium channel subunit alpha, ENaCa, ENaCalpha, Epithelial Na (+) channel subunit alpha, Epithelial Na+ channel subunit alpha, Epithelial Sodium Channel alpha, Epithelial Sodium Channel-α, FLJ21883, Nonvoltage gated sodium channel 1 subunit alpha, Nonvoltage-gated sodium channel 1 subunit alpha, SCNEA, SCNN 1, SCNN1, SCNN1A, SCNNA_HUMAN, Sodium channel nonvoltage gated 1 alpha
UNSPSC
12352203
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Gene ID
25122
Swiss Prot
Q6IRJ1
Accession Number
NP_113736
Cellular Locus
Apical Cell Membrane
Host
Rabbit
Species Reactivity
Human, Rat, Mouse, Xenopus
Immunogen
Produced against a synthetic peptide mapping to the N-terminal of the alpha subunit (amino acids 46-68) of rat Alpha ENaC (antibody designation 3560-2) .
Target
ENaC
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal
Applications
WB | IHC | ICC/IF | IP
Validated Applications
WB, IHC, ICC/IF, IP
Field of Research
Neuroscience | Neurotransmission | Ion Channels | Sodium Channels | Epithelial Sodium Channels (ENaC)
Purification
Protein A Purified
Detection Range
1 µg/ml of SPC-403 was sufficient for detection of alpha-ENaC in 35 µg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Concentration
1 mg/ml
Dilution
WB (1:1000), ICC/IF (1:400) ; IHC (1:25) ; optimal dilutions for assays should be determined by the user.
Weight
0.012
Buffer
PBS, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Kakizoe Y., et al. (2009) J Hpyertens. 27 (8) : 1679-1689. 2. Gu Y. (2008) J Cell Physiol. 216 (2) :453-457. 3. Bruns J.B. (2003) Am J Physiol Renal Physiol. 285 (4) : F600-F609. 4. Mauro T., et al. (2002) J Invest Dermatol. 118 (4) : 589-594. 5. Elias N., et al. (2007) Am J Physiol Lung Cell Mol Physiol. 293 (3) : L537-45. 6. Dyka F.M., May C.A. and Enz R. (2005) J Neurochem. 94 (1) : 120-128.
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
-20ºC
Specificity
Detects ~85kDa.
Species
Human | Rat | Mouse | African clawed frog (Xenopus laevis)
Location
Apical Cell Membrane
Immunogen Species
Rat

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