ENaC beta Antibody

• Background:

  The beta subunit of the epithelial sodium channel (ENaCβ) is essential for the functional assembly and regulation of the ENaC complex, which governs sodium absorption across epithelial surfaces. While ENaCβ is well-characterized in renal and pulmonary physiology, its emerging role in the nervous system is drawing increasing interest in neurodegenerative disease research. ENaCβ is critical for fluid clearance in distal lung epithelia, particularly in response to edema, and its expression is upregulated during keratinocyte differentiation—highlighting its involvement in cellular stress adaptation. In the retina, ENaCβ is differentially expressed under conditions of ocular hypertension, suggesting a role in neurovascular regulation and intraocular pressure homeostasis. These mechanisms are relevant to neurodegenerative diseases where fluid imbalance, oxidative stress, and ion dysregulation contribute to neuronal injury. Recent studies propose that ENaCβ may influence glial cell function, neuroinflammation, and blood-brain barrier integrity—key factors in the progression of disorders such as Parkinson’s disease and ALS. As a regulator of sodium flux and tissue hydration, ENaCβ represents a promising target for modulating neuroimmune responses and preserving neural function. By bridging epithelial ion transport and neural health, ENaCβ offers a novel perspective in the search for biomarkers and therapeutic strategies in neurodegeneration.

• Description:

  Rabbit Anti-Rat ENaC beta Polyclonal

• Specifications:

  Detects ~87kDa.

• Product Name Alternative:

  Amiloride sensitive sodium channel subunit beta, Amiloride-sensitive sodium channel beta-subunit, Beta ENaC, Beta NaCH, ENaC beta, ENaCB, Epithelial Na (+) channel subunit beta, Epithelial Na+ channel beta subunit, Epithelial Na+ channel subunit beta, Epithelial sodium channel beta 2 subunit, Epithelial sodium channel beta 3 subunit, Nonvoltage gated sodium channel 1 beta subunit, Nonvoltage gated sodium channel 1 subunit beta, Nonvoltage-gated sodium channel 1 beta subunit, SCNEB, SCNN 1B, SCNN1B, Sodium channel nonvoltage gated 1 beta, Sodium channel nonvoltage gated 1 beta (Liddle syndrome)

• UNSPSC:

  12352203

• UN Code:

  Non-hazardous

• Hazard Statement:

  Non-hazardous

• Gene ID:

  24767

• Swiss Prot:

  P37090

• Accession Number:

  NP_036780

• Cellular Locus:

  Apical Cell Membrane

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat, Xenopus, Hamster

• Immunogen:

  Produced against the C-terminal tail (amino acids 617-638) of rat beta ENaC (antibody designation 3755-2)

• Target:

  ENaC

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal

• Applications:

  WB | IHC | ICC/IF | IP

• Validated Applications:

  WB, IHC, ICC/IF, IP

• Field of Research:

  Neuroscience | Neurotransmission | Ion Channels | Sodium Channels | Epithelial Sodium Channels (ENaC)

• Purification:

  Protein A Purified

• Detection Range:

  1 µg/ml of SPC-404 was sufficient for detection of beta-ENaC in 20 µg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

• Concentration:

  1 mg/ml

• Dilution:

  WB (1:1000), IHC (1:100) ; optimal dilutions for assays should be determined by the user.

• Weight:

  0.012

• Buffer:

  PBS, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Kakizoe Y., et al. (2009) J Hpyertens. 27 (8) : 1679-1689. 2. Gu Y. (2008) J Cell Physiol. 216 (2) :453-457. 3. Bruns J.B. (2003) Am J Physiol Renal Physiol. 285 (4) : F600-F609. 4. Mauro T., et al. (2002) J Invest Dermatol. 118 (4) : 589-594. 5. Elias N., et al. (2007) Am J Physiol Lung Cell Mol Physiol. 293 (3) : L537-45. 6. Dyka F.M., May C.A. and Enz R. (2005) J Neurochem. 94 (1) : 120-128.

• Shipping Conditions:

  Blue Ice or 4ºC

• Storage Conditions:

  -20ºC

• Specificity:

  Detects ~87kDa.

• Species:

  Human | Mouse | Rat | African clawed frog (Xenopus laevis) | Hamster

• CAS Number:

  9007-83-4

• Location:

  Apical Cell Membrane

• Immunogen Species:

  Rat