CDC37 Antibody

CAT: 0400-SPC-142SSize: 12 µgDry Ice: NoHazardous: No
CAT#:0400-SPC-142SSize:12 µg
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Background
CDC37 is a co-chaperone of HSP90 that plays a pivotal role in stabilizing and directing HSP90 to a wide array of protein kinases, including CDK4, CDK6, SRC, RAF1, and eIF2α kinases. By facilitating the maturation and functional maintenance of these kinases, CDC37 is essential for signal transduction, cell cycle progression, and stress responses. In the nervous system, CDC37’s regulation of kinase stability intersects with pathways critical for neuronal survival, synaptic plasticity, and neuroinflammation. Dysregulation of CDC37 or its client kinases has been implicated in neurodegenerative conditions such as Alzheimer’s disease and Parkinson’s disease, where aberrant kinase signaling contributes to tau hyperphosphorylation, protein aggregation, and neuronal loss. Given its central role in proteostasis and kinase regulation, CDC37 is emerging as a potential therapeutic target for modulating neurodegenerative signaling cascades.
Description
Rabbit Anti-Human CDC37 Polyclonal
CAS Number
9007-83-4
Specifications
Detects ~44.5kDa.
Product Name Alternative
CDC37, Hsp90 co-chaperone Cdc37, Cell division control protein 37, Hsp90 chaperone protein kinase-targeting subunit, CDC37_HUMAN, CDC37A, p50, p50Cdc37, S. cerevisiae hypothetical protein CDC37
UNSPSC
12352203
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Gene ID
11140
Swiss Prot
Q16543
Accession Number
NP_008996.1
Cellular Locus
Cytoplasm
Host
Rabbit
Species Reactivity
Human
Immunogen
Native human Cdc37, full length
Target
CDC37
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal
Applications
IHC | ICC/IF
Validated Applications
WB, ICC/IF
Field of Research
Cancer | Heat Shock | Cell Signaling | Epigenetics and Nuclear Signaling
Purification
Protein A Purified
Detection Range
A 1:2000 dilution of SPC-142 was sufficient for detection of cdc37 in 20 µg of HeLa cell lysate by ECL immunoblot analysis.
Concentration
1.68 mg/ml
Dilution
WB (1:2000), ICC/IF (1:200) ; optimal dilutions for assays should be determined by the user.
Weight
0.012
Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Dai K, Kobayashi R., Beach D. (1996) J Biol Chem. 271 (36) : 22030-22034. 2. Stepanova L, Leng X., Parker S.B., Harper J.W. (1996) Genes Dev. 10 (12) : 1491-1502. 3. Kimura Y., et al. (1997) Genes Dev. 11 (14) : 1775-1185. 4. Gray P.J., et al. (2008) Nat Rev Cancer. 8 (7) : 491-495.
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
-20ºC
Specificity
Detects ~44.5kDa.
Species
Human
Location
Cytoplasm
Immunogen Species
Human

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