CDC37 Protein

• Background:

  HSP90 co-chaperone Cdc37 is a protein that is encoded by the CDC37 gene. It has been found to form complexes with HSP90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF1, MOK and elF-2 alpha kinases. It is thought to play a critical role in directing HSP90 to its target kinases (1, 2). CDC37 is necessary for maintaining prostate tumor cell growth and represents a novel target in the exploration for multi-targeted therapies (3, 4).

• Description:

  Human Recombinant CDC37 Protein

• UNSPSC:

  12352202

• Gene ID:

  11140

• Swiss Prot:

  Q16543

• Accession Number:

  NP_008996.1

• Cellular Locus:

  Cytoplasm

• Host:

  E. coli

• Origin Species:

  Human

• Target:

  CDC37

• Conjugation:

  His tag

• Sequence:

  MGHHHHHHMVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGGKAELERLQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLSKDGFSKSMVNTKPEKTEEDSEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKIKTADRQYMEGFNDELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKASEAKEGEEAGPGDPLLEAVPKTGDEKDVSV

• Applications:

  WB, SDS-PAGE, Functional Assay

• Purification Method:

  Affinity Purified

• Concentration:

  Lot/batch specific. See included datasheet.

• Purity:

  >90%

• Weight:

  0.05

• Buffer:

  25mM Tris buffer pH7.2, 150mM NaCl, 0.1 mM DTT, 50% glycerol

• Molecular Weight:

  ~44.5 kDa

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.

• References & Citations:

  1. Dai K., Kobayashi R., Beach D. (1996) J Biol Chem. 271(36): 22030-22034. 2. Stepanova L., Leng X., Parker S.B., Harper J.W. (1996) Genes Dev. 10(12): 1491-1502. 3. Kimura Y., et al. (1997) Genes Dev. 11(14): 1775-1185. 4. Gray P.J., et al. (2008) Nat Rev Cancer. 8(7): 491-495.