Thalidomide-N-methylpiperazine

• UNSPSC Description:

  Thalidomide-N-methylpiperazine is an E3 Ligase Ligand-Linker Conjugate. Thalidomide-N-methylpiperazine can be used to synthesize PROTAC MLKL Degrader-2 (HY-169072) [1] to exhibit antinecroptotic activity on human cell lines and effectively degrade MLKL in the HT-29 xenograft mouse model[1].

• Target Antigen:

  E3 Ligase Ligand-Linker Conjugates

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/thalidomide-n-methylpiperazine.html

• Smiles:

  CN1CCN(C2=CC3=C(C=C2)C(N(C3=O)C4CCC(NC4=O)=O)=O)CC1

• Molecular Weight:

  356.38

• References & Citations:

  [1]Li S, et al. Discovery of Covalent MLKL PROTAC Degraders via Optimization of a Theophylline Derivative Ligand for Treating Necroptosis. J Med Chem. 2024 Sep 12;67(17):15353-15372.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2924858-30-8