Thalidomide-Pip-N-boc

CAT:

804-HY-161576

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CAS Number: 2636798-54-2
UNSPSC Description: Thalidomide-Pip-N-boc is a conjugate of E3 ligase ligand and linker. Thalidomide-Pip-N-boc is utilized for synthesis of PROTAC Degrader LLC0424 (HY-161574)[1].
Target Antigen: E3 Ligase Ligand-Linker Conjugates
Type: Reference compound
Related Pathways: PROTAC
Applications: Cancer-programmed cell death
Field of Research: Cancer
Assay Protocol: https://www.medchemexpress.com/thalidomide-pip-n-boc.html
Smiles: O=C(OC(C)(C)C)NC1CCN(C2=CC3=C(C(N(C(C(N4)=O)CCC4=O)C3=O)=O)C=C2)CC1
Molecular Weight: 456.49
References & Citations: [1]Liu L, et al., Discovery of LLC0424 as a Potent and Selective in Vivo NSD2 PROTAC Degrader. J Med Chem. 2024 May 9;67(9):6938-6951.
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

Cat	Name
HY-161576	Thalidomide-Pip-N-boc
HY-161208	Deoxy-thalidomide-Pip-C-PIP-boc
HY-161206	Thalidomide-Pip-C-Pip-O-C-boc
HY-161205	Thalidomide-PIP-(R)C-pyrrolidine-boc
HY-161210	Thalidomide-azetidine-C-PIP-C-boc
HY-161209	Thalidomide-2,6-diazaspiro[3.4]octane-C-Pip-boc
HY-161183	(S)-Thalidomide-O-(1S,3r)-C4H4-N(Me)-Pip-C2-O-C-boc
HY-159571	Thalidomide-NH-C5-azacyclohexane-N-Boc
HY-134982-02	Thalidomide-piperazine-Boc
HY-134982-05	Thalidomide-piperazine-Boc