AG-1478

• Description :

  AG-1478 (Tyrphostin AG-1478) is a selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM. AG-1478 has antiviral effects against HCV and encephalomyocarditis virus (EMCV) .

• Product Name Alternative :

  Tyrphostin AG-1478; NSC 693255

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  EGFR; HCV; Influenza Virus

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer; Infection; Metabolic Disease; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/ag-1478.html

• Purity :

  99.57

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  COC1=CC2=NC=NC(NC3=CC=CC(Cl)=C3)=C2C=C1OC

• Molecular Formula :

  C16H14ClN3O2

• Molecular Weight :

  315.75

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Bojko A, et al. The effect of tyrphostins AG494 and AG1478 on the autocrine growth regulation of A549 and DU145 cells. Folia Histochem Cytobiol. 2012 Jul 5;50 (2) :186-95.|[2]Li W, et al. EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice. Sci Rep. 2016 Apr 18;6:24580.|[3]Akhtar S, et al. Cationic Polyamidoamine Dendrimers as Modulators of EGFR Signaling In Vitro and In Vivo. PLoS One. 2015 Jul 13;10 (7) :e0132215.|[4]Dorobantu CM, et al. Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα. Antimicrob Agents Chemother. 2016 Sep 23;60 (10) :6402-6.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  EGFR/ErbB1/HER1

• CAS Number :

  [153436-53-4]