SN-38-d3

• Description:

  SN-38-d3 is the deuterium labeled SN-38. SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively[1][2][3][4].

• Product Name Alternative:

  NK012-d3

• UNSPSC:

  12352005

• Hazard Statement:

  H301

• Target:

  ADC Payload; Autophagy; Topoisomerase

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Antibody-drug Conjugate/ADC Related; Autophagy; Cell Cycle/DNA Damage

• Field of Research:

  Cancer

• Purity:

  98.79

• Solubility:

  DMSO : 25mg/mL (ultrasonic)

• Smiles:

  [2H]C([2H])([2H])CC1=C2C(C(N3C2)=CC([C@](O)(C(OC4)=O)CC)=C4C3=O)=NC5=CC=C(O)C=C51

• Molecular Formula:

  C22H17D3N2O5

• Molecular Weight:

  395.42

• Precautions:

  H301

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Kawato Y, et al. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res. 1991;51 (16) :4187-4191.|[3]Wallin A, et al. Anticancer effect of SN-38 on colon cancer cell lines with different metastatic potential. Oncol Rep. 2008 Jun;19 (6) :1493-8.|[4]Jensen NF, et al. Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a newpair of resistance-associated mutations. J Exp Clin Cancer Res. 2016 Mar 31;35:56.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  [718612-49-8]