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SN-38-CM2

CAT: 0804-HY-157797Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-157797Size:1 Each
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Description
SN-38-CM2 is a split esterase, and shows >95% conversion to SN-38 within 5 min in vitro. SN-38-CM2 induces protein-protein interactions (PPI) -dependent esterase to mediate cell death in MDA-MB-231 cells[1].
CAS Number
2376127-86-3
UNSPSC
12352005
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sn-38-cm2.html
Solubility
10 mM in DMSO
Smiles
O=C(C1(CC1)C)OCO[C@]2(C3=C(COC2=O)C(N4C(C(C(C4)=C(C5=C6)CC)=NC5=CC=C6OCOC(C7(CC7)C)=O)=C3)=O)CC
Molecular Formula
C34H36N2O9
Molecular Weight
616.66
References & Citations
[1]Jones KA, et al. Development of a Split Esterase for Protein-Protein Interaction-Dependent Small-Molecule Activation. ACS Cent Sci. 2019 Nov 27;5 (11) :1768-1776.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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