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DEN1B rabbit pAb

CAT: 0855-ES16970-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES16970-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Clathrin (see MIM 118955) -mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024) . Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]) .[supplied by OMIM, Nov 2010]
Description
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]). [supplied by OMIM, Nov 2010],
UniProt
Q6P3S1
Swiss Prot
Q6P3S1
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human DEN1B AA range: 325-375
Target
DEN1B
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasm, cytosol . Cytoplasmic vesicle, clathrin-coated vesicle .
Gene ID (Human)
163486

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