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DEN1A rabbit pAb

CAT: 0855-ES16971-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES16971-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Clathrin (see MIM 118955) -mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024) . Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]) .[supplied by OMIM, Nov 2010]
Description
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]). [supplied by OMIM, Nov 2010],
UniProt
Q8TEH3
Swiss Prot
Q8TEH3
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human DEN1A AA range: 14-64
Target
DEN1A
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein . Cell junction, synapse, presynaptic cell membrane . Associates to membranes via lipid-binding activity. .
Gene ID (Human)
57706

UniProtKB · Q8TEH3

DENN domain-containing protein 1A

DEN1A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8TEH3
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DENND1A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8MZA3, B1AM80, B7Z3C8, B7Z669, D3PFD3, Q05C88, Q5VWF0, Q6PJZ5, Q8IVD6, Q9H796
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCell projectionCytoplasmic vesicleMembraneSynapse

Molecular function

Guanine-nucleotide releasing factor

Ligand

Lipid-binding

PTM

Phosphoprotein

Biological process

Protein transportTransport

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