Products for Research Use Only
RegisterLogin

BGB-8035

CAT: 0804-HY-149051-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-149051-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
BGB-8035 is an orally active, highly selective bruton's tyrosine kinase (BTK) inhibitor with IC50s of 1.1 nM, 99 nM, 621 nM for BTK, TEC, EGFR, respectively. BGB-8035 has antitumor and anti-arthritis activity. BGB-8035 has the potential for B-cell malignancies and autoimmune diseases research[1].
CAS Number
2283349-24-4
UNSPSC
12352005
Target
Btk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bgb-8035.html
Purity
99.00
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C=CC(N1CCC(CC1)[C@@H]2CCNC3=C(C(C4=CC(OC)=C(C(OC)=C4)C)=NN32)C(N)=O)=O
Molecular Formula
C24H31N5O4
Molecular Weight
453.53
References & Citations
[1]Yunhang Guo, et al. Discovery of BGB-8035, a Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase for B-Cell Malignancies and Autoimmune Diseases. J Med Chem. 2023 Mar 23;66 (6) :4025-4044.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-P991613BGB-A445
HY-15732-01BGB-102
HY-13299-01MK-8033
HY-107143BL-8030
HY-167894DA-8031
HY-13299A-01MK-8033 (hydrochloride)
HY-P1166UFP-803
HY-111192-01IPR-803
HY-W999618CRBN ligand-803
HY-P1166AUFP-803 (TFA)

Alternative Products

CatalogName
M36520-01BGB-8035
BA6386-5BGB-102
JH914116BGB-15025
MBS5764893BGB-290
GTR19217396-01BGB-283
C01600-100mgBGB 15025
GTR17967655Bgb Antibody

Popular Products