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Isosilybin B

CAT: 0804-HY-N7045-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N7045-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Isosilybin B is a flavonolignan. Isosilybin B can be isolated from Silybum marianum. Isosilybin B can regulate cell cycle-related proteins (e.g., reduce cyclins (D3, D1, A, E), Cdk4, Cdk2, Cdc25A), and activate Caspases (Caspase-9 and Caspase-3) . Isosilybin B can promote Apoptosis, reduce androgen receptor (AR) and PSA. Isosilybin B has anticancer activity against prostate cancer[1][2].
CAS Number
142796-22-3
UNSPSC
12352005
Hazard Statement
H302
Target
Androgen Receptor; Apoptosis; Caspase; CDK; PSMA
Type
Natural Products
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/isosilybin-b.html
Purity
99.32
Solubility
10 mM in DMSO
Smiles
O=C1[C@H](O)[C@@H](C2=CC=C(O[C@@H](C3=CC=C(O)C(OC)=C3)[C@H](CO)O4)C4=C2)OC5=CC(O)=CC(O)=C15
Molecular Formula
C25H22O10
Molecular Weight
482.44
Precautions
H302
References & Citations
[1]Deep G, et al. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostatecancer LNCaP and 22Rv1 cells. Carcinogenesis. 2007 Jul;28 (7) :1533-42.|[2]Deep G, et al. Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway. Oncogene. 2008 Jun 26;27 (28) :3986-98.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 9; CDK2; CDK4

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