Isosilybin

• Description:

  Isosilybin (Isosilybinin) is a flavonoid from Silybum marianum; inhibits CYP3A4 induction with an IC50 of 74 μM.

• Product Name Alternative:

  Isosilybinin

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Cytochrome P450

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Isosilybin.html

• Purity:

  99.95

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C1[C@H](O)[C@@H](C2=CC=C(OC(C3=CC=C(O)C(OC)=C3)C(CO)O4)C4=C2)OC5=CC(O)=CC(O)=C15

• Molecular Formula:

  C25H22O10

• Molecular Weight:

  482.44

• Precautions:

  H302

• References & Citations:

  [1]Mooiman KD, et al. Milk thistle's active components silybin and isosilybin: novel inhibitors of PXR-mediated CYP3A4 induction. Drug Metab Dispos. 2013 Aug;41 (8) :1494-504.|[2]Deep G, et al. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer LNCaP and 22Rv1 cells. Carcinogenesis. 2007 Jul;28 (7) :1533-42.|[3]Deep G, et al. Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway. Oncogene. 2008 Jun 26;27 (28) :3986-98.|[4]Pferschy-Wenzig EM, et al. Identification of isosilybin a from milk thistle seeds as an agonist of peroxisome proliferator-activated receptor gamma. J Nat Prod. 2014 Apr 25;77 (4) :842-7.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  CYP3

• CAS Number:

  [72581-71-6]