Isosilybin A

CAT: 0931-MF-0013513-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0013513-01Size:25 mg
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CAS Number
142796-21-2
Target
NF-?B|||Apoptosis|||p38 MAPK|||Androgen Receptor|||ABC Transporter|||ERK|||PPAR|||Tyrosinase
Related Pathways
NF-?B|||Endocrinology/Hormones|||DNA Damage/DNA Repair|||Membrane transporter/Ion channel|||MAPK|||Apoptosis|||Metabolism|||Proteases/Proteasome
Purity
0.9988
Bioactivity
Isosilybin A is a partial PPAR? agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6?M) and diphenolase (IC50=12.1-44.9?M) of tyrosinase. Isosilybin A shows anti-angiogenic efficacy, it has anti-prostate cancer (PCA) activity that is mediated via cell cycle arrest and apoptosis induction.
Smiles
COc1cc(ccc1O)[C@H]1Oc2ccc(cc2O[C@@H]1CO)[C@H]1Oc2cc(O)cc(O)c2C(=O)[C@@H]1O
Molecular Formula
C25H22O10
Molecular Weight
482.44
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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