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Isosilybin A

CAT: 0804-HY-N7043-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N7043-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Isosilybin A is a PPARγ agonist that can be isolated from silymarin. Isosilybin A activates extrinsic and intrinsic pathways of apoptosis through targeting of the Akt-NF-kB-AR axis. Isosilybin A can relieve the inflammatory response in the rosacea model via inhibiting Erk and p38 signaling pathways and M1 macrophage polarization, with its targets related to RELA and VEGFA. Isosilybin A has anti-prostate cancer (PCA) activity[1][2][3].
CAS Number
142796-21-2
UNSPSC
12352005
Hazard Statement
H302
Target
Androgen Receptor; Apoptosis; ERK; NF-κB; p38 MAPK; PPAR
Type
Natural Products
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/isosilybin-a.html
Concentration
10mM
Purity
99.63
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1[C@H](O)[C@@H](C2=CC=C(O[C@H](C3=CC=C(O)C(OC)=C3)[C@@H](CO)O4)C4=C2)OC5=CC(O)=CC(O)=C15
Molecular Formula
C25H22O10
Molecular Weight
482.44
Precautions
H302
References & Citations
[1]Wu CC, et al. Isosilybin A exhibits anti-inflammatory properties in rosacea by inhibiting MAPK pathway and M1 macrophage polarization. Int Immunopharmacol. 2024 Dec 25;143 (Pt 1) :113323. |[2]Pferschy-Wenzig EM, et al. Identification of isosilybin a from milk thistle seeds as an agonist of peroxisome proliferator-activated receptor gamma. J Nat Prod. 2014 Apr 25;77 (4) :842-7.|[3]Deep G, et al. Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-κB, and androgen receptor signaling. Mol Carcinog. 2010 Oct;49 (10) :902-12.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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