Isosilybin A

• Description:

  Isosilybin A is a PPARγ agonist that can be isolated from silymarin. Isosilybin A activates extrinsic and intrinsic pathways of apoptosis through targeting of the Akt-NF-kB-AR axis. Isosilybin A can relieve the inflammatory response in the rosacea model via inhibiting Erk and p38 signaling pathways and M1 macrophage polarization, with its targets related to RELA and VEGFA. Isosilybin A has anti-prostate cancer (PCA) activity[1][2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Androgen Receptor; Apoptosis; ERK; NF-κB; p38 MAPK; PPAR

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/isosilybin-a.html

• Concentration:

  10mM

• Purity:

  99.63

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C1[C@H](O)[C@@H](C2=CC=C(O[C@H](C3=CC=C(O)C(OC)=C3)[C@@H](CO)O4)C4=C2)OC5=CC(O)=CC(O)=C15

• Molecular Formula:

  C25H22O10

• Molecular Weight:

  482.44

• Precautions:

  H302

• References & Citations:

  [1]Wu CC, et al. Isosilybin A exhibits anti-inflammatory properties in rosacea by inhibiting MAPK pathway and M1 macrophage polarization. Int Immunopharmacol. 2024 Dec 25;143 (Pt 1) :113323. |[2]Pferschy-Wenzig EM, et al. Identification of isosilybin a from milk thistle seeds as an agonist of peroxisome proliferator-activated receptor gamma. J Nat Prod. 2014 Apr 25;77 (4) :842-7.|[3]Deep G, et al. Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-κB, and androgen receptor signaling. Mol Carcinog. 2010 Oct;49 (10) :902-12.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [142796-21-2]