CXCR4-IN-3

CXCR4-IN-3

• UNSPSC Description: CXCR4-IN-3 (compound XVI) is an orally active and potent inhibitor targeting the inflammation-related receptor CXCR4, with an IC50 of 3.2 nM. CXCR4-IN-3 exhibits potent antichemotactic activity, at 79.19±2.33% inhibition. CXCR4-IN-3 shows anti-inflammatory activity. CXCR4-IN-3 can be used for IBD (inflammatory bowel disease) research[1].
• Target Antigen: CXCR
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Immunology/Inflammation
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/cxcr4-in-3.html
• Smiles: O=C(C1=CC=CO1)N2CCN(C3CCN(C4=CC=CC=C4)CC3)CC2
• Molecular Weight: 339.43
• References & Citations: [1]Jiang X, et al. Synthetically Feasible De Novo Molecular Design of Leads Based on a Reinforcement Learning Model: AI-Assisted Discovery of an Anti-IBD Lead Targeting CXCR4. J Med Chem. 2024 Jun 27;67(12):10057-10075.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported