CXCR4-IN-2

• UNSPSC Description:

  CXCR4-IN-2 (compound A1) is a bifunctional fluorinated small molecule that is a potent CXCR4 inhibitor with anticancer activity. CXCR4-IN-2 has cytotoxic (IC50: 60 μg/mL; 72 h) and antiproliferative effects on mouse colorectal cancer (CRC) cells. CXCR4-IN-2 induces cell arrest in the G2/M phase and induces apoptosis[1].

• Target Antigen:

  Apoptosis; CXCR

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;GPCR/G Protein;Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/cxcr4-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=CC=C(/N=C(NC(N/C(C(F)(F)F)=N/C2=CC(C)=C(C)C=C2)=S)\C(F)(F)F)C=C1C

• Molecular Weight:

  474.47

• References & Citations:

  [1]Khorramdelazad H, et al. Antitumor activities of a novel fluorinated small molecule (A1) in CT26 colorectal cancer cells: molecular docking and in vitro studies. J Biomol Struct Dyn. 2023 Sep 13:1-14.. .

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported