RegisterLogin

Toceranib-d8

CAT: 0804-HY-10330SSize: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-10330SSize:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Toceranib-d8 is the deuterium labeled Toceranib. Toceranib (SU11654) is an orally active receptor tyrosine kinase (RTK) inhibitor, and it potently inhibits PDGFR, VEGFR, and Kit with Kis of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively. Toceranib (SU11654) has antitumor and antiangiogenic activity, and used in the treatment of canine mast cell tumors[1][2].
CAS Number
[1795134-78-9]
UNSPSC
12352005
Hazard Statement
H315, H319
Target
C-Kit; Isotope-Labeled Compounds; PDGFR; VEGFR
Type
Isotope-Labeled Compounds
Related Pathways
Others; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
99.08
Solubility
10 mM in DMSO
Smiles
C(=C1C=2C(NC1=O)=CC=C(F)C2)C3=C(C)C(C(NCCN4C(C(C(C4([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])=O)=C(C)N3
Molecular Formula
C22H17D8FN4O2
Molecular Weight
404.51
Precautions
H315, H319
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]London CA, et al. Phase I dose-escalating study of SU11654, a small molecule receptor tyrosine kinase inhibitor, in dogs with spontaneous malignancies. Clin Cancer Res. 2003 Jul;9 (7) :2755-68.|[3]Halsey CH, et al. Development of an in vitro model of acquired resistance to toceranib phosphate (Palladia?) in canine mast cell tumor. BMC Vet Res. 2014 May 6;10:105.|[4]Mitchell L, et al. Clinical and immunomodulatory effects of toceranib combined with low-dose cyclophosphamide in dogs with cancer. J Vet Intern Med. 2012 Mar-Apr;26 (2) :355-62.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-10330-01Toceranib
HY-10330A-01Toceranib (phosphate)
HY-B1618S-01Corticosterone-d8
HY-10455S-01Carfilzomib-d8
HY-B0684S-01Iopamidol-d8
HY-14598S-01Diethylstilbestrol-d8
HY-14588S1Lopinavir-d8
HY-14542SZiprasidone-d8
HY-13585SCarmustine-d8
HY-15414SVortioxetine-d8

Alternative Products

CatalogName
TRC-T525502-100MGToceranib-d8
M22125-01Toceranib
MBS3840970-01Toceranib phosphate
467694-01Toceranib discontinued
206590Toceranib free base
A15263-5Toceranib phosphate 5mg
A15263-10Toceranib phosphate 10mg
A15263-200Toceranib phosphate 200mg

Popular Products